{"id":5084,"date":"2024-01-08T13:40:30","date_gmt":"2024-01-08T12:40:30","guid":{"rendered":"https:\/\/www.ptc.cz\/sto-lijecimo\/prostata\/jak-poznat-rakovinu-prostaty\/psa\/"},"modified":"2024-06-21T14:46:28","modified_gmt":"2024-06-21T12:46:28","slug":"prostata-specificni-antigen-psa","status":"publish","type":"page","link":"https:\/\/www.ptc.cz\/hr\/sto-lijecimo\/prostata\/rak-prostate\/prostata-specificni-antigen-psa\/","title":{"rendered":"Prostata specifi\u010dni antigen – PSA"},"content":{"rendered":"

Test PSA
\n<\/strong><\/h3>\n

Pokud se hodnota PSA v krvi zv\u00fd\u0161\u00ed nad stanoven\u00fd limit (ur\u010duje se podle v\u011bku a velikosti prostaty!), je doporu\u010deno prov\u00e9st dal\u0161\u00ed vy\u0161et\u0159en\u00ed prostaty, zejm\u00e9na vy\u0161et\u0159en\u00ed per rectum, ultrazvukov\u00e9 vy\u0161et\u0159en\u00ed, magnetickou rezonanci prostaty, biopsii prostaty.<\/h4>\n

Pro mu\u017ee ve v\u011bku 40 \u2013 49 let byla navr\u017eena horn\u00ed hranice PSA 2,5 ng\/ml, v 50 \u2013 59 letech 3,5 ng\/ml, v 60 \u2013 69 letech 4,5 ng\/ml a od 70 let v\u00fd\u0161e 6,5 ng\/ml.*<\/strong><\/p>\n

\n
\n
\n

Prostatick\u00fd specifick\u00fd antigen (PSA) je v\u00a0sou\u010dasnosti klinicky nejv\u00fdznamn\u011bj\u0161\u00edm ukazatelem (markerem)\u00a0karcinomu prostaty. Je to enzym produkovan\u00fd norm\u00e1ln\u00edmi i\u00a0rakovinov\u00fdmi bu\u0148kami prostaty a\u00a0vy\u0161et\u0159en\u00ed jeho koncentrace v\u00a0krvi je b\u011b\u017en\u011b pou\u017e\u00edvanou metodou v\u00a0diagnostice karcinomu prostaty.\u00a0Zkratka PSA ozna\u010duje b\u00edlkovinu, kterou produkuj\u00ed \u017el\u00e1zky prostaty.<\/p>\n

Z\u00e1kladn\u00ed funkc\u00ed b\u00edlkoviny PSA je zkapaln\u011bn\u00ed spermatu, jej\u00ed nejv\u011bt\u0161\u00ed koncentrace je tedy v semeni a jen mal\u00e1 \u010d\u00e1st je uvoln\u011bna do krve. Ka\u017ed\u00fd mu\u017e s prostatou m\u00e1 tedy ur\u010ditou hladinu PSA. V p\u0159\u00edpad\u011b, \u017ee je struktura bun\u011bk a \u017el\u00e1zek prostaty po\u0161kozen\u00e1 (nap\u0159\u00edklad pr\u00e1v\u011b n\u00e1dorem prostaty), se PSA dost\u00e1v\u00e1 do krve ve vy\u0161\u0161\u00edm mno\u017estv\u00ed.<\/p>\n

Vy\u0161et\u0159en\u00ed krve na stanoven\u00ed hladiny PSA se prov\u00e1d\u00ed nejen u mu\u017e\u016f s p\u0159\u00edznaky onemocn\u011bn\u00ed rakoviny prostaty (jako je nap\u0159\u00edklad obt\u00ed\u017en\u00e9 mo\u010den\u00ed, probl\u00e9my s erekc\u00ed \u010di bolesti v p\u00e1nvi a z\u00e1dech apod.), ale prov\u00e1d\u00ed se tak\u00e9 u mu\u017e\u016f bez p\u0159\u00edznak\u016f jako preventivn\u00ed vy\u0161et\u0159en\u00ed. \u00dasp\u011bch l\u00e9\u010dby zhoubn\u00fdch n\u00e1dor\u016f je t\u00e9m\u011b\u0159 v\u017edy z\u00e1visl\u00fd na v\u010dasn\u00e9m rozpozn\u00e1n\u00ed zhoubn\u00e9ho tumoru a p\u0159esn\u00e9m stanoven\u00ed diagn\u00f3zy.<\/p>\n<\/div>\n<\/div>\n

\n
\n

Zv\u00fd\u0161enou hladinu celkov\u00e9ho PSA v s\u00e9ru m\u016f\u017eeme pozorovat u karcinomu prostaty, ale i u jin\u00fdch onemocn\u011bn\u00ed, nap\u0159. benign\u00ed hyperplazie prostaty, z\u00e1n\u011btu prostaty, p\u0159i akutn\u00ed retenci mo\u010di \u010di po n\u011bkter\u00fdch urologick\u00fdch manipulac\u00edch. Objevuje se tak\u00e9 po pohlavn\u00edm styku. N\u011bkter\u00e9 typy n\u00e1dor\u016f prostaty ale na hladinu PSA v krvi bohu\u017eel nemus\u00ed m\u00edt \u017e\u00e1dn\u00fd vliv. Proto je nezbytn\u00e9 tak\u00e9 dopl\u0148uj\u00edc\u00ed vy\u0161et\u0159en\u00ed \u201eper rectum\u201c<\/strong>.<\/p>\n

** Hodnota PSA je z\u00e1visl\u00e1 na v\u011bku a velikosti prostaty, proto pro ka\u017ed\u00e9ho individu\u00e1ln\u00edho mu\u017ee existuje m\u00edrn\u011b odli\u0161n\u00e1 \u201enorm\u00e1ln\u00ed\u201c hladina PSA. Za norm\u00e1ln\u00edch okolnost\u00ed je hladina PSA v\u00a0s\u00e9ru pod 4 ng\/ml, co\u017e je hodnota, kter\u00e1 je mezin\u00e1rodn\u011b uzn\u00e1van\u00e1 jako d\u011bl\u00edc\u00ed linie mezi norm\u00e1ln\u00ed a\u00a0zv\u00fd\u0161enou hodnotou PSA. Pot\u00ed\u017ee p\u0159i\u00a0diagnostice karcinomu prostaty prost\u0159ednictv\u00edm m\u011b\u0159en\u00ed PSA zp\u016fsobuje fakt, \u017ee a\u017e 20\u00a0% pacient\u016f se\u00a0zhoubn\u00fdm n\u00e1dorem m\u00e1 hladinu PSA ni\u017e\u0161\u00ed ne\u017e 4 ng\/ml a\u00a0naopak zdaleka ne ka\u017ed\u00fd pacient s\u00a0PSA v\u00a0hodnot\u00e1ch 4 \u2013 10 ng\/ml m\u00e1 karcinom prostaty. Hovo\u0159\u00edme o\u00a0tzv.\u00a0diagnostick\u00e9 \u0161ed\u00e9 z\u00f3n\u011b, ve\u00a0kter\u00e9 se\u00a0karcinom vyskytuje pouze u\u00a025% pacient\u016f.<\/p>\n<\/div>\n<\/div>\n<\/div>\n

*citov\u00e1no dne 8.1.2024\u00a0z https:\/\/urosante.cz\/urologie\/prostaticky-specificky-antigen\/<\/h6>\n
** citov\u00e1no dne 8.1.2024 z https:\/\/www.cus.cz\/pro-pacienty\/diagnozy\/karcinom-prostaty\/ a https:\/\/urosante.cz\/urologie\/prostaticky-specificky-antigen\/<\/h6>\n","protected":false},"excerpt":{"rendered":"

Test PSA Pokud se hodnota PSA v krvi zv\u00fd\u0161\u00ed nad stanoven\u00fd limit (ur\u010duje se podle v\u011bku a velikosti prostaty!), je doporu\u010deno prov\u00e9st dal\u0161\u00ed vy\u0161et\u0159en\u00ed prostaty, zejm\u00e9na vy\u0161et\u0159en\u00ed per rectum, ultrazvukov\u00e9 vy\u0161et\u0159en\u00ed, magnetickou rezonanci prostaty, biopsii prostaty. Pro mu\u017ee ve v\u011bku 40 \u2013 49 let byla navr\u017eena horn\u00ed hranice PSA 2,5 ng\/ml, v 50 \u2013 59 letech 3,5 ng\/ml, v 60…<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":5082,"menu_order":463,"comment_status":"closed","ping_status":"closed","template":"template-service-detail-with-sidebar.php","meta":{"footnotes":""},"class_list":["post-5084","page","type-page","status-publish","hentry"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.ptc.cz\/hr\/wp-json\/wp\/v2\/pages\/5084","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ptc.cz\/hr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ptc.cz\/hr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ptc.cz\/hr\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ptc.cz\/hr\/wp-json\/wp\/v2\/comments?post=5084"}],"version-history":[{"count":1,"href":"https:\/\/www.ptc.cz\/hr\/wp-json\/wp\/v2\/pages\/5084\/revisions"}],"predecessor-version":[{"id":5129,"href":"https:\/\/www.ptc.cz\/hr\/wp-json\/wp\/v2\/pages\/5084\/revisions\/5129"}],"up":[{"embeddable":true,"href":"https:\/\/www.ptc.cz\/hr\/wp-json\/wp\/v2\/pages\/5082"}],"wp:attachment":[{"href":"https:\/\/www.ptc.cz\/hr\/wp-json\/wp\/v2\/media?parent=5084"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}